Cooling-induced changes in intracellular hydrogen peroxide and gene expression in mouse skeletal muscle in vivo

Hideki SHIRAKAWA

doi:10.1152/ajpregu.00014.2025

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Cooling-induced changes in intracellular hydrogen peroxide and gene expression in mouse skeletal muscle in vivo

ジャーナル論文 - rm_published_papers: Scientific Journal

査読済み

Cooling-induced changes in intracellular hydrogen peroxide and gene expression in mouse skeletal muscle in vivo

Hideki SHIRAKAWA

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol.328(6), ページR758-R766

01/06/2025

DOI: https://doi.org/10.1152/ajpregu.00014.2025

抄録

This in vivo model successfully characterized the effects of cooling on cytosolic and mitochondrial [H₂O₂] in mouse tibialis anterior skeletal muscle. Cooling decreased [H₂O₂] down to ∼13°C, but the effect was reversed at still lower temperatures. Sustained cooling decreased mRNA levels of antioxidant-related genes (Sod2, Cat, and Ucp3), whereas intermittent cooling increased Nrf mRNA expression. These results help elucidate the mechanistic bases for skeletal muscle adaptation to cooling.

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詳細

タイトル: Cooling-induced changes in intracellular hydrogen peroxide and gene expression in mouse skeletal muscle in vivo
作成者 – 役職なし: Hideki SHIRAKAWA
出版物に関する詳細: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol.328(6), ページR758-R766
出版者: American Physiological Society
ID: 991002621781807421
組織: The University of Electro-Communications
言語: 英語
資料タイプ: ジャーナル論文
リソースのサブタイプ: rm_published_papers: Scientific Journal