Eccentric contraction increases hydrogen peroxide levels and alters gene expression through Nox2 in skeletal muscle of male mice

Daisuke HOSHINO

doi:10.1152/japplphysiol.00335.2024

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Eccentric contraction increases hydrogen peroxide levels and alters gene expression through Nox2 in skeletal muscle of male mice

ジャーナル論文 - rm_published_papers: Scientific Journal

査読済み

Eccentric contraction increases hydrogen peroxide levels and alters gene expression through Nox2 in skeletal muscle of male mice

Daisuke HOSHINO

Journal of Applied Physiology, Vol.137(3), ページ778-788

01/09/2024

DOI: https://doi.org/10.1152/japplphysiol.00335.2024

抄録

This in vivo model successfully characterized the effects of eccentric (ECC) and concentric (CONC) contractions on cytosolic and mitochondrial [H₂O₂] in mouse skeletal muscle. Compared with CONC, ECC induced higher and more sustained [H₂O₂]_cyto—an effect that was abolished by Nox2 inhibition. ECC-induced [H₂O₂]_cyto elevations were requisite for altered gene expression.

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詳細

タイトル: Eccentric contraction increases hydrogen peroxide levels and alters gene expression through Nox2 in skeletal muscle of male mice
作成者 – 役職なし: Daisuke HOSHINO
出版物に関する詳細: Journal of Applied Physiology, Vol.137(3), ページ778-788
出版者: American Physiological Society
ID: 991002559496007421
組織: The University of Electro-Communications
資料タイプ: ジャーナル論文
リソースのサブタイプ: rm_published_papers: Scientific Journal