抄録
Offer Organization: Japan Society for the Promotion of Science, System Name: Grants-in-Aid for Scientific Research, Category: Grant-in-Aid for Scientific Research (C), Fund Type: -, Overall Grant Amount: - (direct: 3600000, indirect: 1080000)
Photostimulation to transgenic mice expressing light-sensitive cation channel, channelrhodopsin-2, in astrocyte or neuron elicited intensity-dependent increase in cortical blood flow. Pharmacological study exhibited specific mechanism of astrocyte- or neuron-originated microcirculatory control.
Cortical spreading depression (CSD) involving mass depolarization of neuron and astrocyte elicited transient constriction and dilation of pial and intraparenchymal penetrating artery, followed by mild constriction, and deceleration of red blood cell (RBC) flowing in capillary in parallel with arterial constriction. Repeated CSD elicited marked dilation of penetrating artery and acceleration of RBC. Spontaneous occurrence of CSD during transient middle cerebral artery occlusion by modified Tamura's method may be involved in formation and/or development of infarction. Susceptibility to CSD was enhanced and recovery from CSD was elongated in familial hemiplegic migraine 2 model mice.