抄録
Offer Organization: Japan Society for the Promotion of Science, System Name: Grants-in-Aid for Scientific Research, Category: Grant-in-Aid for Scientific Research (B), Fund Type: competitive_research_funding, Overall Grant Amount: - (direct: 13700000, indirect: 4110000)
In order to develop the foundation for designing molecular computers which can execute various computational functions according to sequences of external control signals, we devised novel computational models with unknown behaviors which can be controlled by external signals, novel DNA devices responsive to external signals, a new sequence design system for finding DNA sequences for temperature dependent DNA devices, and finally collected data and knowledge which are important when using two different DNA devices in a system. The theoretical and experimental research discussions enabled to find an important knowledge that, when we construct a system, we need to partition reactions into reversible and irreversible ones based on their computational functions. Furthermore, the development of the new photo-responsive device makes us distinguish a single base difference of input DNA sequences, which suggests an important improvement in the developed computational models.