抄録
Offer Organization: Japan Society for the Promotion of Science, System Name: Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Category: Grant-in-Aid for Early-Career Scientists, Fund Type: -, Overall Grant Amount: - (direct: 3200000, indirect: 960000)
We examined the effects of clenbuterol administration and resistance training that induce muscle hypertrophy on metabolic adaptation in skeletal muscles and adipose tissues. Clenbuterol administration decreased the expression of proteins involved in mitochondrial fusion and fission, and increased abnormal morphological mitochondria in skeletal muscle. At the same time, there was no change in nuclear translocation of histone deacetylase 4 (HDAC4). Four-week resistance training reduced subcutaneous white adipocyte size and increased the protein levels of mitochondrial enzymes in brown adipose tissue. It is necessary to further clarify the mechanism of the above experimental results.