抄録
Offer Organization: Japan Society for the Promotion of Science, System Name: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Category: Grant-in-Aid for Scientific Research (C), Fund Type: -, Overall Grant Amount: - (direct: 3600000, indirect: 1080000)
To elucidate the regulatory mechanism for Ca^<2+> influx pathway in fertilized mammalian eggs, we conducted a series of molecular and physiological experiments to interfere the interactions between Ca^<2+> influx channels on the plasma membrane, TRPC and Orai, and proteins on the ER membrane, STIM. The results suggested that, although none of these proteins participate functionally in the maintenance of the Ca^<2+> oscillations by activating Ca^<2+> influx, STIM1 may have an novel role other than as an activator of store-operated Ca^<2+> entry.