抄録
Offer Organization: Japan Society for the Promotion of Science, System Name: Grants-in-Aid for Scientific Research, Category: Grant-in-Aid for Scientific Research (B), Fund Type: -, Overall Grant Amount: - (direct: 13400000, indirect: 4020000)
Recently, abnormalities in frequency discrimination have been observed in some patients with abnormal sound perception, but the cause of these abnormalities is unknown and there are no objective diagnostic criteria. We reported the mice with abnormal frequency discrimination and confirmed the predicted abnormal propagation of basal menbrane vibration from basal (high frequency) to apical (low frequency) rotation. We further elucidated the possible causes of this abnormality by simulating the cochlear model and suggested the possiblity that high frequency hearing loss model abnormally recognize the sound as a low frequency sound. Furthermore, by developing a technology to generate cochlear cells from iPS cells, they were able to reproduce the pathophysiology of hearing loss and succeeded in generating hair cells using the same method, which is expected to lead to clinical applications of inner ear cell therapy in the future.