Masumi TAKI (瀧真清)

0110300_Ⅲ類（理工系）, 0110000_情報理工学域, The University of Electro-Communications

bioTCI combinatorial screening

Middle-to-Macro Biomolecular Targeted Covalent Inhibitor (bioTCI)

covalent aptamer

covalent drug | 共有結合性薬剤

middle-molecule drug discovery | 中分子創薬

mechano-chemistry / mechano-biology | メカノケミストリー・メカノバイオロジー

molecular-evolution engineering | 進化分子工学

NEXT-A reaction

extended phage display

peptidic covalent binder

chemical biology

ジャーナル論文 - rm_published_papers: Scientific Journal 査読済み

ARCaDia: single-round screening of a DNA-type targeted covalent binder possessing a latent warhead

by Masumi TAKI

公開済 12/2024

Chemical Communications, 60, 100, 14964 - 14967

A covalent binder was identified using a single-round screening from a latent-warhead-modified DNA library, coupled with top k-mer analysis to pinpoint the optimal warhead position on the aptamer.

図書

Complementing Stability and Affinity of a Linear Peptidic Binder by Adapting Retro-Inverso to a Peptidic Covalent Binder, Peptide Science 2023: p.81-82

by Masumi TAKI

公開済 08/2024

図書

Discovery and Characterization of a Short Peptide Possessing a Latent Warhead Undergoing Intramolecular Cyclization in the Aqueous Environment, Peptide Science 2023: p.27-28

by Masumi TAKI

公開済 08/2024

ジャーナル論文 - rm_misc: Introduction Scientific Journal 査読済み

Peptidic Targeted Covalent Inhibitors (TCIs) possessing Stability in Serum

by Masumi TAKI

公開済 04/2024

PEPTIDE NEWSLETTER JAPAN, 132, 4 - 6

ジャーナル論文 - rm_published_papers: Scientific Journal 査読済み

bioTCIs: Middle-to-Macro Biomolecular Targeted Covalent Inhibitors Possessing Both Semi-Permanent Drug Action and Stringent Target Specificity as Potential Antibody Replacements

by Masumi TAKI

公開済 02/2023

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24, 4

ジャーナル論文 - rm_published_papers: Scientific Journal 査読済み

Relative Nuclease Resistance of a DNA Aptamer Covalently Conjugated to a Target Protein

by Masumi TAKI

公開済 14/07/2022

International Journal of Molecular Sciences, 23, 7778

ジャーナル論文 - rm_published_papers: Scientific Journal 査読済み

Solvatochromic peptidic binder obtained via extended phage display acts as a fluororeporter for fragment-based drug discovery (FBDD)

by Masumi TAKI

公開済 04/06/2022

Anal. Bioanal. Chem, 414, 4803 - 4807

図書

Construct of cyclic peptide phage library containing covalent warhead, Peptide Science 2021

by Masumi TAKI

公開済 03/2022

図書

Reversal of covalent conjugation of benzoxaborole-modified targeted peptide by reduction, Peptide Science 2021

by Masumi TAKI

公開済 03/2022

図書

Direct combinatorial screening of a target-specific covalent binding peptide: activation of the warhead reactivity in a pseudo-catalytic microenvironment, Peptide Science 2021

by Masumi TAKI

公開済 03/2022

Masumi TAKI (瀧 真清)

0110300_Ⅲ類（理工系）, 0110000_情報理工学域, The University of Electro-Communications

研究業績リスト

Masumi TAKI (瀧真清)